About halushi-behcet's syndrome

What is halushi-behcet's syndrome?

Behcet's syndrome is a rare multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. Symptoms include mucous membrane lesions of the mouth (canker sores) and genitals (ulcers) that tend to disappear and recur spontaneously. Inflammation of the eyes (anterior uveitis, posterior uveitis, or panuveitis) also affects individuals with Behcet's syndrome. Additional systems of the body may also be affected including the joints, blood vessels, central nervous system, and/or digestive tract. The exact cause of Behcet's syndrome is unknown.

What are the symptoms for halushi-behcet's syndrome?

Canker sore symptom was found in the halushi-behcet's syndrome condition

Areas commonly affected by Behcet's disease include:

  • Mouth. Painful mouth Sores that look similar to canker Sores are the most common sign of Behcet's disease. They begin as raised, round lesions in the mouth that quickly turn into painful ulcers. The Sores usually heal in one to three weeks, though they do recur.
  • Skin. Some people develop acnelike Sores on their bodies. Others develop red, raised and tender nodules on their skin, especially on the lower legs.
  • Genitals. Red, open Sores can occur on the scrotum or the vulva. The Sores are usually painful and can leave scars.
  • Eyes. Inflammation in the eye (uveitis) causes redness, Pain and blurred vision, typically in both eyes. In people with Behcet's disease, the condition can come and go.
  • Joints. Joint swelling and Pain often affect the knees in people with Behcet's disease. The ankles, elbows or wrists also might be involved. Signs and symptoms can last one to three weeks and go away on their own.
  • Blood vessels. Inflammation in veins and arteries can cause redness, pain, and swelling in the arms or legs when a blood clot results. Inflammation in the large arteries can lead to complications, such as aneurysms and narrowing or blockage of the vessel.
  • Digestive system. A variety of signs and symptoms can affect the digestive system, including abdominal pain, diarrhea and bleeding.
  • Brain. Inflammation in the brain and nervous system can cause headache, fever, disorientation, poor balance or stroke.

What are the causes for halushi-behcet's syndrome?

Behcet's disease might be an autoimmune disorder, which means the body's immune system mistakenly attacks some of its own healthy cells. It's likely that genetic and environmental factors play a role.

The signs and symptoms of Behcet's disease are considered to be due to inflammation of the blood vessels (vasculitis). The condition can involve arteries and veins of all sizes, damaging them throughout the body.

Several genes have been found to be associated with the disease. Some researchers believe a virus or bacterium can trigger Behcet's disease in people who have certain genes that make them susceptible to Behcet's.

What are the treatments for halushi-behcet's syndrome?

There's no cure for Behcet's disease. If you have a mild form, your doctor might suggest medications to control the pain and inflammation of flares. You might not need medication between flares.

For more-severe signs and symptoms, your doctor might prescribe medications to control the Behcet's disease throughout your body, in addition to medications for flares.

Treatments for individual signs and symptoms of Behcet's disease

Medications to control signs and symptoms you have during flares might include the following:

  • Skin creams, gels and ointments. Topical corticosteroid medicines are applied directly to skin and genital sores to reduce inflammation and pain.
  • Mouth rinses. Using special mouthwashes that contain corticosteroids and other agents might reduce the pain of mouth sores.
  • Eyedrops. Eyedrops containing corticosteroids or other anti-inflammatory medicines can relieve pain and redness in your eyes if inflammation is mild.

Systemic treatments for Behcet's disease

If topical medications don't help, your doctor might recommend a drug called colchicine (Colcrys, Mitigare) for recurring oral and genital sores. Joint swelling also might improve with colchicine.

Severe cases of Behcet's disease require treatments to control damage from the disease between flares. If you have moderate to severe Behcet's disease, your doctor might prescribe:

  • Corticosteroids to control inflammation. Corticosteroids, such as prednisone, are used reduce the inflammation caused by Behcet's disease. Doctors often prescribe them with another medication to suppress the activity of your immune system.

    Side effects of corticosteroids include weight gain, persistent heartburn, high blood pressure and bone thinning (osteoporosis).

  • Medications that suppress your immune system. The inflammation associated with Behcet's disease can be reduced by drugs that prevent your immune system from attacking healthy tissues. These drugs may include azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune) and cyclophosphamide. These drugs can increase your risk of infection. Other possible side effects include liver and kidney problems, low blood counts, and high blood pressure.
  • Medications that alter your immune system's response. Interferon alfa-2b (Intron A) regulates the activity of your immune system to control inflammation. It may be used alone or with other drugs to help control skin sores, joint pain and eye inflammation in people with Behcet's disease. Side effects include flu-like signs and symptoms, such as muscle pain and fatigue.

    Medications that block a substance called tumor necrosis factor (TNF) are effective in treating some of the signs and symptoms of Behcet's, especially for people who have more-severe or resistant symptoms. Examples include infliximab (Remicade) and adalimumab (Humira). Side effects might include headache, skin rash and an increased risk of infections.

What are the risk factors for halushi-behcet's syndrome?

Factors that might increase your risk of Behcet's include:

  • Age. Behcet's disease commonly affects men and women in their 20s and 30s, though children and older adults also can develop the condition.
  • Where you live. People from countries in the Middle East and East Asia, including Turkey, Iran, Japan and China, are more likely to develop Behcet's.
  • Sex. While Behcet's disease occurs in both men and women, the disease is usually more severe in men.
  • Genes. Having certain genes is associated with a higher risk of developing Behcet's.

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